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Deniz Isin was born on 28 May 1992 in Izmir. She graduated with a bachelor's degree in chemical engineering from Ege University and got her master's degree in materials science and engineering from the same university. She then took acting lessons for two years in Izmir, then she attracted attention with her videos she have posted on the Scorp Platform. After appearing in a number of TV commercials, Isin had her first television acting with FOX's Her Yerde Sen. She then had a supporting role on Iyi Günde Kötü Günde and in Sefirin Kizi. Additionally, she featured in the music video for Murat Boz's song "Gece". She played the character Irem in the TV series Masumiyet. She played in action film "Anka Kusu" and comedy film "Ask Cagirirsa Gelir". She was in new version of hit surreal comedy series Leyla ile Mecnun which 8 years after finale, started shooting again for a digital platform. She wrote and played in short comedy series "Eee Sonra"/"Bizden Olur Mu" which published in Youtube and later Blutv. She played in short film "Oluler Icin Yasam Kilavuzu". She played in ATV series "Sevmek Zamani". However, the series ended after five episodes due to low ratings. She later played in "9 Oguz", but the series ended after six episodes due to low ratings.
